Inventions
Dr. Chou has made remarkable cross-disciplinary advances in translational medicine, marked by scientific discoveries and the development of novel medical modalities. These innovations have benefited tens of millions worldwide, especially those afflicted by severe wounds and bone defects. Moreover, through the donation of millions of products to developing countries with individuals facing life-threatening wounds, Dr. Chou’s philanthropic efforts have had a profound impact on global health.
Pioneered the Field of Molecular Biocompatibility
In 1995, Dr. Chou was the first to discover element- and topography-specific biogenetic reactions to inert biomaterials within live human cells. This breakthrough sparked the emergence of the molecular biocompatibility field. Dr. Chou’s proposal of building the biomaterials’ molecular biocompatibility profile is credited with catalyzing the development of third-generation biomaterials and played a key role in shaping the federal white paper “Materials Genome Initiative” issued by President Obama in 2011.
The First Epitheliogenic Biomaterials Benefiting over 16 Millions Patients Worldwide
Dr. Chou’s groundbreaking research on Si/Ca-containing epitheliogenic materials paved the way for the creation of FDA-, CFDA-, or CE-approved wound-healing medications, protected by 56 patents. By February 2024, these medications have effectively treated 16,503,900 patients suffering from severe bedsores, donor-skin loss, deep burns, delayed-healing wounds, and diabetic foot ulcers. Additionally, Dr. Chou’s philanthropic efforts include the donation of 1,679,868 packaged products to regions in Africa and other developing nations, providing crucial aid to individuals with life-threatening wounds.
- Selected Animal Study for Wound Healing
- Translating the Inventions into a Series of Products Named DERMLIN
- Selected Patients Treated Successfully with DERMLIN
- Severe surgical incision wound treated successfully
- Severely injured fingers treated successfully
- Severe diabetic foot ulcer treated successfully
- Severe pressure ulcer treated successfully
- Severe electric burn treated successfully
- Severe stasis ulcer treated successfully
- Patents Covering the Invention and Production of DERMLIN
- Articles Published by Independent Clinicians Using DERMLIN
- Success in treating diabetic foot ulcers
- Success in treating deep second- and third-degree burn wounds
- Success in treating severe pressure wounds (Bedsore)
- Success in treating surgical incision wounds
- Success in treating radiotherapy-associated wounds
- Success in treating large surgical wounds after cancer surgery and lymph node dissection
- Success in treating other wounds
The First 3D Printing Device for Tissue Engineering and First Biomimetically Engineered Scaffold Benefiting Over a Hundred Thousand Patients
In 1998, Dr. Chou uncovered the osteogenic properties of inorganic silicon, along with its synergistic relationship with calcium. His pioneering work included the development of the world’s first 3-D printing method for tissue engineering in 1995. This breakthrough culminated in the creation of the first CFDA-approved biomimetically engineered osteogenic scaffold for treating severe bone defects. As of February 2024, this scaffold has facilitated bone regeneration in 142,750 patients, boasting nearly zero short- or long-term failure rates based on over 20 years of post-operative monitoring.
- Inventions of osteogenic materials, biomimetic scaffold, and the First 3D printing device for tissue engineering
- The osteogenic role of Silicon first discovered by Dr. Chou in 1995
- The first biomimetic scaffold designed by Dr. Chou for bone tissue engineering
- The first 3D printing device developed by Dr. Chou for tissue engineering
- In Vivo Studies of Bone Tissue Engineering
- The first engineered human bone tissue
- The first success in repairing a segmental bone defect
- Translating Inventions into a Series of Products Named OSTEOBONE
- Selected Patients Treated with OSTEOBONE Bone Scaffold Products
- The first patient with an over 25-year long-term follow-up after treatment with Dr. Chou’s innovative technology
- The second patient with an over 25-year long-term follow-up after treatment by Dr. Chou’s innovative technology
- Large mandible defect treated successfully
- Bone donner site treated successfully
- Bone defect after benign bone tumor removal treated successfully
- Bone fracture treated successfully
- Patents covering the invention and production of OSTEOBONE
- Articles Published by Independent Clinicians Using OSTEOBONE
The First Oral Ulcer Healing Material Helping Over a Million Patients
Around 20% of the world’s population suffers from recurrent oral ulcers, a condition for which, prior to 2006, steroid use was the primary treatment option despite associated side effects. In 2006, Dr. Chou introduced the first silicon delivery patch, approved by FDA, CFDA, or CE, for faster healing of oral ulcers without relying on steroids. As of February 2024, 1,801,013 patients have benefited from this innovative product for managing recurrent oral ulcers.
- Translating the Inventions into a Product Named ULCELOOCIN
- Selected Patients Treated with ULCELOOCIN
- Patents Covering the Invention and Production of ULCELOOCIN
The First Head and Neck PET/CT System for Better Diagnosis and Treatment of Cancer Patients
In 2016, Dr. Chou and his team introduced the first Head and Neck PET-CT scanner, tailored for diagnosing and monitoring head and neck cancer. Their efforts yielded 55 patents, spanning the scanner’s distinctive signaling system and design, which achieves twice the resolution with 70 percent less radiation compared to existing full-body PET-CT scans. This design enables immediate assessment of surgical outcomes following tumor removal in the head and neck region. There is additional potential to address diagnostic gaps in Alzheimer’s disease and monitoring treatment progress. Clinical trials under CFDA approval are forthcoming for this scanner.
- The World’s First Head and Neck PET/CT Device
- Advanced Animal PET/SPECT/CT Series
- Mira®, Micro PET/CT with the highest resolution in the world
- Mars®, the world’s first animal SPECT/CT
- Sirius®, the world’s first animal PET/SPECT/CT
- Super Nova® pre-clinical in-vivo PET/CT
- Patents Covering the Invention and Production of Molecular Imaging System (PET/SPECT/CT)
- Growing Body of Publications enabled by Pingseng Devices
The First Nano-Sensor to Detect the Early-Stage Lung and Gastric Cancer from a Breath Sample
Dr. Chou has led a team in developing a novel breath test nano-sensor device for the early detection of lung and gastric cancer. With 42 patents to its name, this technology detects trace biochemical markers of cancer cells, even before clinical symptoms appear. An initial clinical study, approved by the IRB and involving 545 patients with early-stage lung and gastric cancers, demonstrated 100 percent accuracy and sensitivity. A larger clinical trial is currently in progress. The device’s successful development could revolutionize cancer screening by offering a non-invasive method based on a simple breath sample.
- The Prototype of the World’s First Nano-Sensor for Lung and Gastric Cancer Detection on a Breath Sample
- Preliminary Data of an IRB-Approved Clinical Trial
- Patents Covering the Invention and Production of Breath Nano-Sensor for Lung and Gastric Cancer Detection